Effects of Rosmarinus officinalis and Platanus orientalis extracts on asthmatic subjects resistant to routine treatments | ||
| Avicenna Journal of Phytomedicine | ||
| مقاله 236، دوره 8، شماره 5، آذر و دی 2018، صفحه 399-407 اصل مقاله (545.4 K) | ||
| نوع مقاله: Original Research Article | ||
| شناسه دیجیتال (DOI): 10.22038/ajp.2018.25278.1925 | ||
| نویسندگان | ||
| Majid Mirsadraee* 1؛ Afsaneh Tavakoli2؛ Vahideh Ghorani3؛ Shadi Ghafari4 | ||
| 1Department of Internal medicine, Faculty of Medicine, Islamic Azad University-Mashhad Branch, Mashhad, Iran | ||
| 2Innovative Medical Research Center, Department of pharmacology, Mashhad Branch, Islamic Azad University, Mashhad, Iran | ||
| 3Neurogenic Inflammation Research Centre and Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
| 4Biologist, Shahid Hasehemi Nezhad Research center, Kavosh high school, Ministry of Education, Mashhad, Iran | ||
| چکیده | ||
| Objective: The present study aimed to determine the effects of Rosmarinus officinalis (R. officinalis) and Platanus orientalis(P. orientalis) extracts on asthma. Materials and Methods: We conducted a randomized, double-blind, active-comparator study to evaluate the effect of P. orientalis and R. officinalis extracts on asthmatic patients resistant to routine treatment.The subjects were randomly divided into three groups receiving P. orientalis and R. officinalis extracts alone or in combination. The primary endpoints were clinical findings, spirometry, exhaled nitric oxide (FENO) and Asthma Control Test (ACT) assessed over the one-month treatment period. Results: ACT score showed significant improvement after treatment with R. officinalis (p<0.05) but not with P. orientalis. Clinical evaluations showed that cough, sputum production and wheezing were significantly improved in R. officinalis group (p Conclusion: R. officinalis extract showed promising results in treatment of resistant asthma. Further studies to find the most effective components of these herbal medicines are recommended. | ||
| کلیدواژهها | ||
| Asthma؛ R. officinalis؛ P. orientalis؛ Sycamore؛ Rosmarinic acid | ||
| مراجع | ||
|
Aggarwal BB, Shishodia S. 2004. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann N Y Acad Sci, 1030:434-41.
Al-Sereiti MR, Abu-Amer KM, Sen P. 1999. Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. Indian J Exp Biol, 37:124-130.
Aqel MB. 1991. Relaxant effect of the volatile oil of Rosmarinus officinalis on tracheal smooth muscle. J Ethnopharm, 33:57-62.
Bai N, He K, Roller M, Lai C, Shao X, Pan M, Ho C. 2010. Flavonoids and Phenolic Compounds from Rosmarinus officinalis. J Agric Food Chem, 58: 5363–5367.
Chirumbolo S. 2010. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets, 9:263-285.
Eftekhar N, Moghimi A, Boskabady MH. 2017. Prophylactic effect of rosmarinic acid on tracheal responsiveness, white blood cell count and oxidative stress markers in lung lavage of sensitized rats. In Press, Accepted Manuscript by Pharmacol Rep.
Emami F, Ali-Beig H, Farahbakhsh S, Mojabi N, Rastegar-Moghadam B, Arbabian S, Kazemi M, Tekieh E, Golmanesh L, Ranjbaran M, Jalili C, Noroozzadeh A, Sahraei H. 2013. Hydroalcoholic extract of Rosemary (Rosmarinus officinalis L.) and its constituent carnosol inhibit formalin-induced pain and inflammation in mice. Pak J Biol Sci, 16: 309-316.
Encyclopedia Iranica. Vol. V, Fasc. 2, pp. 129-133. Available at: http://www.iranicaonline.org/articles/cenar-the-oriental-plane-tree-platanus-orientalis-l.
Global initiative for asthma, Pocket guide for asthma management and prevention. National institute of health, National heart, lung and blood institute, Publication 96-3659B, 1998:1-29.
Hajhashemi V, Ghannadi A, Mousavi S. 2011. Antinociceptive study of extracts of Platanus orientalis leaves in mice. Res Pharm Sci, 6: 123–128.
Inoue K, Takano H, Shiga A, Fujita Y, Makino H, Yanagisawa R, Ichinose T, Kato Y, Yamada T, Yoshikawa T. 2005. Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice. Int J Mol Med, 16:315-319.
Irtiza S, Bhat GA, Ahmad M, Ganaie HA, Ganai BA, Kamili AN, Akbar S, Tantry MA. 2016. Antioxidant and Anti-inflammatory Activities of Platanus orientalis: An Oriental Plant Endemic to Kashmir Planes. Pharmacologia, 7:217-222.
Mehni F, Sharififar F, Ansari M. 2012. Antioxidant activity and rosmarinic acid content of ten medicinal plants. Res Pharmac Sci, 7: 780.
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CPM, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wangere J. 2005. Standardization of spirometry. Eur Respir J, 26: 319-338.
Mitrokotsa D, Mitaku S, Demetzos C, Harvala C, Mentis A, Perez S, Kokkinopoulos D. 1993. Bioactive compounds from the buds of Platanus orientalis and isolation of a new kaempferol glycoside. Planta Med, 59:517-520.
Pazouki N, Sankian M, Nejadsattari T, Khavari-Nejad RA, Varasteh AR. 2008. Oriental plane pollen allergy: identification of allergens and cross-reactivity between relevant species. Allergy Asthma Proc, 29:622-628.
Pazouki N, Sankian M, Leung PT, Nejadsattari T, Khavari-Nejad RA, Varasteh AR. 2009. Identification of cyclophilin as a novel allergen from Platanus orientalis pollens by mass spectrometry. J Biosci Bioeng, 107:215-227.
Pengelly A, Snow J, Mills SY, Scholey A, Wesnes K, Butler LR. 2012. Short-Term Study on the Effects of Rosemary on Cognitive Function in an Elderly Population. J Med Food, 15:10–7.
Rasoolijazi H, Mehdizadeh M, Soleimani M, Nikbakhte F, Farsani ME, Ababzadeh S. 2015. The effect of rosemary extract on spatial memory, learning and antioxidant enzymes activities in the hippocampus of middle-aged rats. Med J Islam Repub Iran, 29: 1-11.
Sahiner UM, Birben E, Erzurum S, Sackesen C and Kalayci O. 2011. Oxidative Stress in Asthma. World Allergy Organ J, 4: 151–158.
Stansbury J. 2014. Rosmarinic Acid as a Novel Agent in the Treatment of Allergies and Asthma. J Report Med, 3:121-126.
Swarup V, Ghosh J, Ghosh S, Saxena A, Basu A. 2007. Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of Japanese encephalitis. Antimicrob Agents Chemother, 51: 3367-3370.
Ulbricht C, Abrams TR, Brigham A, Ceurvels J, Clubb J, Curtiss W, Kirkwood CD, Giese N, Hoehn K, Iovin R, Isaac R, Rusie E, Serrano JMG, Varghese M, Weissner W, Windsor RC. 2010. An Evidence-Based Systematic Review of Rosemary (Rosmarinus officinalis) by the Natural Standard Research Collaboration. J Diet Supple, 4: 351-413. | ||
|
آمار تعداد مشاهده مقاله: 11,996 تعداد دریافت فایل اصل مقاله: 1,640 |
||