Cavallo, Marco, Sayyed-Hosseinian, Sayyed-Hadi, Parma, Alessandro, Buda, Roberto, Mosca, Massimiliano, Giannini, Sandro. (1396). Combination of bone marrow derived cells transplantation and high tibial osteotomy in early osteoarthritis of knee: A preliminary study. , 6(2), 112-118. doi: 10.22038/abjs.2018.28168.1728
Marco Cavallo; Sayyed-Hadi Sayyed-Hosseinian; Alessandro Parma; Roberto Buda; Massimiliano Mosca; Sandro Giannini. "Combination of bone marrow derived cells transplantation and high tibial osteotomy in early osteoarthritis of knee: A preliminary study". , 6, 2, 1396, 112-118. doi: 10.22038/abjs.2018.28168.1728
Cavallo, Marco, Sayyed-Hosseinian, Sayyed-Hadi, Parma, Alessandro, Buda, Roberto, Mosca, Massimiliano, Giannini, Sandro. (1396). 'Combination of bone marrow derived cells transplantation and high tibial osteotomy in early osteoarthritis of knee: A preliminary study', , 6(2), pp. 112-118. doi: 10.22038/abjs.2018.28168.1728
Cavallo, Marco, Sayyed-Hosseinian, Sayyed-Hadi, Parma, Alessandro, Buda, Roberto, Mosca, Massimiliano, Giannini, Sandro. Combination of bone marrow derived cells transplantation and high tibial osteotomy in early osteoarthritis of knee: A preliminary study. , 1396; 6(2): 112-118. doi: 10.22038/abjs.2018.28168.1728

Combination of bone marrow derived cells transplantation and high tibial osteotomy in early osteoarthritis of knee: A preliminary study

The Archives of Bone and Joint Surgery
مقاله 5، دوره 6، شماره 2، خرداد 2018، صفحه 112-118    اصل مقاله (1.14 M)
نوع مقاله: RESEARCH PAPER
شناسه دیجیتال (DOI): 10.22038/abjs.2018.28168.1728
نویسندگان
Marco Cavallo1؛ Sayyed-Hadi Sayyed-Hosseinian* 2؛ Alessandro Parma1؛ Roberto Buda1؛ Massimiliano Mosca1؛ Sandro Giannini1
1Department of Orthopaedics and Traumatology, Rizzoli Orthopaedic Institute, Via Pupilli, Bologna, Italy
2Orthopedic Research Center, Shahid Kamyab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Purpose: high tibial osteotomy (HTO) is a recommended treatment for medial compartment knee osteoarthritis. Newer cartilage regenerative procedures may add benefits to the result of HTO. In this prospective study we investigate safety and also results of HTO associated with bone marrow derived cells (BMDC) transplantation in relatively young and middle aged active individuals with early osteoarthritis of the knee and our hypothesis is combination of these procedures is safe and leads to better outcome.
Methods: 24 patients (with mean age of 47.9 years) with varus knee and symptomatic medial compartment osteoarthritis were treated with medial opening-wedge high tibial osteotomy in conjunction with transplantation of bone marrow derived cells into the chondral lesions. Clinical outcome was assessed by IKDC score, KOOS score, VAS and Tegner scores and radiographic study was performed preoperatively and at follow-ups.
Results: there were no major complications during operation and postoperative follow-ups.all the clinical scores significantly were improved for the IKDC score (from 32.7 +/-15 to 64+/- 21), KOOS score (from30 +/- 11 to 68 +/- 19), VAS (from7.5 to 3), and Tegner score (from 1.2 to 2.1).
Conclusions: HTO in conjunction with BMDC transplantation is a safe and feasible treatment for early medial compartment osteoarthritis in varus knees and associated with good results in short term follow up.
کلیدواژه‌ها
High tibial osteotomy؛ Osteoarthritis؛ bone marrow derived cells transplantation؛ Stem cells؛ cartilage repair
مراجع
آمار
تعداد مشاهده مقاله: 838
تعداد دریافت فایل اصل مقاله: 678
دانشگاه علوم پزشکی مشهد
آمار
تعداد نشریات29
تعداد شماره‌ها2,321
تعداد مقالات24,818
تعداد مشاهده مقاله82,449,241
تعداد دریافت فایل اصل مقاله45,640,629