Anti-inflammatory activity and chemical composition of Pycnocycla bashagardiana fruit’s essential oil in animal models | ||
| Iranian Journal of Basic Medical Sciences | ||
| مقاله 11، دوره 21، شماره 2، اردیبهشت 2018، صفحه 188-193 اصل مقاله (949.37 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22038/ijbms.2017.20860.5426 | ||
| نویسندگان | ||
| Fatemeh Jahandar1؛ Jinous Asgarpanah2؛ Parvaneh Najafizadeh3، 4؛ Zahra Mousavi* 4 | ||
| 1Herbal Medicines Research Center, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran | ||
| 2Department of Pharmacognosy, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran | ||
| 3Department of Pharmacology, Iran University of Medical Sciences, Tehran, Iran | ||
| 4Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran | ||
| چکیده | ||
| Objective(s): Pycnocycla bashagardiana is an endemic species found only in Iran. Due to the presence of myristicin as the major component of the fruit’s oil we were prompted to assess the antinociceptive and anti-inflammatory properties of P. bashagardiana fruit’s essential oil (PBFEO). Materials and Methods: The analgesic activities of PBFEO (100, 200, and 400 mg/kg, IP) were studied by hot-plate and formalin tests in mice. Control and standard groups received vehicle and morphine (5 mg/kg, IP), respectively. The acute anti-inflammatory effect of PBFEO (200 and 400 mg/kg, IP) were assessed by carrageenan-induced paw edema method in 30 min, 1, 2, 3, and 4 hr after carrageenan injection and the chronic anti-inflammatory effect of PBFEO (50 and 100 mg/kg, IP) were assessed by the cotton pellet-induced granuloma method in rats. Results: In hot-plate and formalin tests, the studied doses of PBFEO were not effective. However, in carrageenan test, all studied doses ofPBFEO significantly reduced the paw edema in comparison to the control animals (P<0.05). Anti-inflammatory activity of PBFEO(200 and 400 mg/kg, P<0.05) was found to be more than mefenamic acid (30 mg/kg). In cotton pellet-induced granuloma, PBFEO was also effective regarding the transudate and granuloma formation amount. PBFEO was analyzed by gas chromatography-mass spectrometry and 12 constituents, representing 96.0% of the oil, were identified. The major component of the oil was characterized as myristicin which might be responsible for the anti-inflammatory activity. Conclusion: The results suggest that PBFEOpossesses biologically active constituents that have significant peripheral anti-inflammatory effects. | ||
| کلیدواژهها | ||
| Anti-inflammatory Antinociceptive؛ Essential oil؛ Mice؛ Pycnocycla bashagardiana Mozaff؛ Rat | ||
| مراجع | ||
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